Internal Medicine and Medical Investigation Journal

ISSN: 2474-7750

A Comparative Study of the Detection of cAMP response element binding protein (CREB) in the Peripheral Blood of Alzheimer's Patients and the Healthy subjects as a Biomarker for the diagnosis of Alzheimer


Author(s): Masih Falahatian *, Ahmad Chitsaz

Alzheimer's disease is a neurodegenerative disease, which usually helps

some biomarkers, such as amyloid proteins, to diagnose the disease. Therefore, the

purpose of this study was to compare the expression of a protein binding protein to the

adjuvant responder to circular adenosine monophosphate (CREB) in peripheral blood

of patients to Alzheimer's and healthy elderly people as a biomarker for diagnosing


Materials and Methods:

In this case-control study, 32 patients with

Alzheimer's disease and 32 normal blood samples were taken. Using real time PCR,

CREB expression was evaluated.


The mean CREB level in the case group was

0.89 ± 0.30 and in the control group was 1.01 ± 0.03. The mean of BDNF level in the

case group was significantly higher than the control group (P <0.001). There was no

significant relationship between the level of CREB with age, sex, MMSE score and

Cornell scale for depression in dementia (P> 0.05).


Reducing CREB

levels in people with Alzheimer's disease can be a factor in diagnosis in comparison to

healthy people.

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