Author(s): Masih Falahatian *, Ahmad Chitsaz
Alzheimer's disease is a neurodegenerative disease, which usually helps
some biomarkers, such as amyloid proteins, to diagnose the disease. Therefore, the
purpose of this study was to compare the expression of a protein binding protein to the
adjuvant responder to circular adenosine monophosphate (CREB) in peripheral blood
of patients to Alzheimer's and healthy elderly people as a biomarker for diagnosing
Materials and Methods:
In this case-control study, 32 patients with
Alzheimer's disease and 32 normal blood samples were taken. Using real time PCR,
CREB expression was evaluated.
The mean CREB level in the case group was
0.89 ± 0.30 and in the control group was 1.01 ± 0.03. The mean of BDNF level in the
case group was significantly higher than the control group (P <0.001). There was no
significant relationship between the level of CREB with age, sex, MMSE score and
Cornell scale for depression in dementia (P> 0.05).
levels in people with Alzheimer's disease can be a factor in diagnosis in comparison to