Author(s): Negin Vermzyar, Fatemeh Keshavarzi, Nader Rashahmadi
Introduction: Prostate cancer is the second most lethal cancer in men after lung cancer in world. Genetic predisposition is fast emerging as risk factor for prostate cancer. The HOXB13 gene is a tumor suppressor gene for prostate cancer and other cancers. The present study was conducted to evaluate G84E mutation of HOXB13 in patients with prostate cancer in Kurdistan and Kermanshah provinc-es of Iran. Materials and Methods: DNA was extracted from blood samples of cases of Benign Prostatic Hyperplasia and 75 healthy control. The G84E muta-tion of HOXB13 was determined by direct sequencing. All statistical calculations were performed using SPSS version17. Results: DNA sequencing results showed that the genotype of this site was GGA in all cases and controls. Conclusion: The results of this study showed that the GOXE position of the HOXB13 gene was not associated with prostate cancer in selected patients of west Iran. This finding showed doesn’t a statistically significant difference in carrier frequency highlights the genetic predispositions to prostate cancer with respect to G84E mutation of HOXB13 gene.