Internal Medicine and Medical Investigation Journal

ISSN: 2474-7750

Comparing the Conventional with Low Dose of Bupivacaine Plus Fentanyl in Spinal Anesthesia on the Neonate Apgar Score in Yazd City


Author(s): Masoud Khoshbin, Ahmad Shajari,Golzar Sharifian

Introduction: Spinal anesthesia is the preferred method of anesthesia in cesarean section, due to less complications. The augmentation of opioids to spinal anesthetics can improve the quality and increase the duration of analgesia. This study aimed to compare the conventional with low dose of bupivacaine plus fentanyl in spinal anesthesia on the neonate Apgar score in elective cesarean section. Methods: The present double-blind randomized clinical trial was conducted on 150 pregnant moth-ers undergoing cesarean section with the spinal anesthesia during 2017-2018. The mothers were randomly assigned to two groups of 75. The spinal anesthesia was per-formed in the first group with the injection of 15 mg of 0.5% hyperbaric bupivacaine plus 1 ml of normal saline, and in the second group with the injection of 12.5 mg of 0.5% hyperbaric bupivacaine plus 25 μg of fentanyl. For both groups, 1- and 5-min-ute neonatal Apgar scores were assessed. Finally, the data were analyzed by SPSS17 software using statistical tests. Results: The mean age of the samples was 30.1±5.19 years with a range of 18-42 years (P-value=0.246). The mean gestational age was 38 weeks, the mean 1-minute Apgar score was 8.88 and the mean 5-minute Apgar score was 9.89 Conclusion: With the augmentation of fentanyl to bupivacaine for spinal anesthesia, the conventional dose can be reduced, which not only reduces the com-mon side effects of Marcainee, but also provides an appropriate level of anesthesia and does not affect the neonatal Apgar score.

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