Internal Medicine and Medical Investigation Journal

ISSN: 2474-7750

Corroboration of Spiral Computed Tomography Angiography with D-Dimer Assays in The Accurate Diagnosis of Pulmonary Embolism and Assessment of Its Image Quality


Author(s): FarheenRazvi *, Taranpreet Singh Kocchar , Tejas Kumar Mansukhlal Sejani , Gao Jian Bo

Pulmonary embolism is a frequent cause of mortality and morbidity.

Aim of this study was to evaluate the utility of spiral computed tomographic angiogra-

phy in determining the prevalence of pulmonary embolism in a clinically suspicious

group and to assess the image quality of a single source computed tomography in

diagnosis of pulmonary embolism. We have also investigated the reliability of D-dimer

test in ruling out pulmonary embolism.

Image quality, was assessed by analyzing the attenuation in the pulmonary trunk and its

branches in comparison with the background noise. Mean attenuation values and

standard deviation were recorded and displayed in Hounsfield Units. The computed

tomography values, standard deviation values and signal-noise ratio obtained were then

statistically analyzed using SPSS 17.0 software.

D-dimer test results were also obtained for the patients suspected of pulmonary

embolism using rapid D-dimer testing and a reference range of 0 – 0.3 μg/l was consid-

ered as normal.


Spiral computed tomography was a valuable method for identifying 20

patients with pulmonary embolism (sensitivity, 100%). It could correctly exclude

pulmonary embolism in 28 out of 30 non - pulmonary embolism cases yielding a

specificity of 94%.In 10 of the 20 patients devoid of pulmonary embolism; Spiral

computed tomography provided an alternate clinical diagnosis. In the remaining 10

patients, spiral computed tomographic angiography scans were normal. The statistical

analysis of the computed tomography values standard deviation and signal-noise ratio

of the pulmonary trunk and pulmonary artery (without right or left predilection)

showed a p-value>0.05. D-dimer Test showed elevated levels in 18 patients who were

diagnosed with pulmonary embolism on spiral computed tomography scans. 8 patients

without pulmonary embolism on spiral computed tomography scans also showed elevat-

ed D-dimer levels. The remaining 22 patients had normal D-dimer levels.


Spiral computed tomography has a good sensitivity and specificity for the

diagnosis of pulmonary embolism. In the majority of patients who did not have pulmo-

nary embolism, it provided important ancillary information for the final diagnosis.

Therefore, combining Spiral computed tomography scan with a D-dimer Test is more

effective in the accurate diagnosis of pulmonary embolism

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