Author(s): Kimia Vatani, Mohammad Amin Hatami Nemati
Introduction: Pemphigus foliaceus is an autoimmune disease with bullous man-ifestations on the surface of the skin that requires long-term administration of immunosuppressive medications. Kaposi’s sarcoma is one of the diseases that manifest in people with innate or acquired immune systems deficiency with the direct involvement of HHV-8 and causes polypoid skin lesions. Case presenta-tion: This study was conducted on a 78-year-old man with a history of pemphigus foliaceus treated with immunosuppressive drugs. Conclusion: In this patient, a secondary polypoid lesion had been created around the anus and the results of pathological tests had confirmed the Kaposi’s Sarcoma.