Internal Medicine and Medical Investigation Journal

ISSN: 2474-7750

Evaluation of Survival Rates and Patterns of Risk Factors and Recurrence Rates in Patients with Triple-Negative Breast Cancer with Other Subtypes


Author(s): Seyed Mohammadreza Mortazavizadeh, Nasrollah Bashardoost, Saeed Kargar, Raziyeh Yazdanpanah

Introduction: Breast cancer a major health concern, especially in industrialized countries. Despite extensive research, a consensus does not yet exist regarding the association between breast cancer risk factors and its many outcomes. Because of the increasing rate of breast cancer in Iran, including in Yazd City, in this study we evaluated the relationship between survival and recurrence rates and patterns of risk factors in breast cancer patients. Methods: This analytical study was conducted retrospectively on 333 patients with breast cancer over an 8-year period (2005-2013). Total survival and recurrence rates were recorded in monthfor all patients; then the data were analyzed with the chi-square and log-rank tests and compared to other obtained data. Kaplan-Meier curves were used to analyze survival data. Results: The mean patient age was 57.02 ± 12.32 years. The mean total survival rate was 93.15 ± 1.25 months (97.9%). The mean total recurrence rate was 84.59 ± 1.91 months (89.8%). Patients in all breast cancer subgroups had no significant relationship with risk factors (P>0.05), although body mass index (BMI) and recurrence rate were significantly related (P=0.045). Other risk factors were not significantly related to total survival and recurrence rates. The mean duration of oral contraceptive pill consumption was significantly longer in patients in the estrogen receptor-progesterone receptor-HER2-positive subgroup than in other groups (P=0.03). Conclusion: We found that BMI lower than 25 kg/m2 was strong prognostic factor for recurrence in patients with triple-negative breast cancer. Because of the high survival rate of patients with breast cancer during our 8-year study period, we recommend that studies with larger sample sizes that are focused on survival period be conducted

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