Internal Medicine and Medical Investigation Journal

ISSN: 2474-7750

Longitudinal Tissue Velocity and Deformation Imaging in Patients with Significant Stenosis of Left Anterior Descending Artery


Author(s): Reyhaneh Zavar, Hakimeh Sadeghian, Masoumeh Lotfi-Tokaldany, Mohammad Moein Ashrafi, Mahmood Sheikh Fathollahi, Afsaneh Sadeghian



Myocardial longitudinal tissue velocity imaging and strain rate imaging

indices may have a role in the prediction of significant proximal stenosis of left anterior

descending by echocardiography.

Materials and Methods:

Total 20 patients with proximal

left anterior descending stenosis >70% by angiography and ejection fraction ≥50%, without

wall motion abnormality at resting echo (stenotic group) and 20 angiographically normal

coronaries subjects with normal echocardiography (non-stenotic group) were included in

the study. Strain rate imaging and tissue velocity imaging were performed in nine segments

of the left anterior descending territory at rest. Parameters of interest included: peak systolic

strain (%), strain rate (Second


), and peak systolic velocity (Sm, cm/s).




mean systolic strain and strain rate showed a significant reduction in the stenotic group

compared to non-stenotic group (


<0.001), while the mean Sm had no significant difference.

A segment-by-segment comparison revealed a reduction of systolic strain in 4/9 (two apical

and two anteroseptal) and strain rate in 5/9 (three apical, septal, and anteroseptal midportion)

in the stenotic group (


<0.05). Both systolic strain and strain rate showed a significant

reduction in three segments: anterior-apical, lateral-apical, and anteroseptal midportion.


: There is an overall reduction in the mean systolic strain and strain rate in the

segments of left anterior descending territory with significant proximal stenosis and normal

wall motion at rest and an acceptable specificity and sensitivity of strain rate imaging for the

detection of stenosis in these segments.

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