Internal Medicine and Medical Investigation Journal

ISSN: 2474-7750

Preemptive Effect of Two Different (Intracuff and Intravenous) Routes of Dexamethasone Administration on Postoperative Sore Throat and Cough


Author(s): Nedasadat Mansouritehrani

The most common complications following anesthesia intubation

include postoperative sore throat, post-extubation cough, and hoarse voice. Currently,

the use of preoperative Dexamethasone has been effective in controlling these complica-

tions. Therefore, the present study aimed to compare the preemptive effect of intracuff

and intravenous routes of Dexamethasone administration for postoperative sore throat

and cough.

Materials and Methods:

In the present clinical trial, 96 patients who under-

went general anesthesia intubation were randomly assigned to three groups. The first

group received 4 mg intracuff Dexamethasone, the second group received 4 mg intrave-

nous Dexamethasone, and the third group was administered a placebo. Cough frequen-

cy and severity of a sore throat after extubation were investigated in the three groups.


Any significant difference was not observed among the three groups regarding

hemodynamic variables (P>0.01); however, the incidence of cough was significantly

lower in all the three groups (P<0.01). Also, the average severity of a sore throat in

PAR and 1 h after surgery in the three groups was significantly lower (P<0.05). Moreo-

ver, no difference was detected in the groups regarding the severity of a sore throat

within 24 h post-surgery (P>0.01).


The use of two methods of intravenous

and intracuff Dexamethasone administration before surgery reduced the incidence of

postoperative cough and the severity of sore throat in patients

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