Author(s): Afshin Amini1, Mahmoud Ali Kaykhaei2, Zahra Vaezi2, Alireza Bakhshipour
Several studies indicate a higher prevalence of fracture following long
term utilization of proton pump inhibitors, among them omeprazole is the most
widely used. However, the exact mechanisms lead to this complication are largely
unknown. We studied short term effects of omeprazole on some markers of calcium
metabolism.
Materials and Methods:
In thirty young adult patients with gastroe-
sophageal reflux, omeprazole was prescribed at 20 mg twice daily for thirty days.
Baseline characteristics as well as data after treatment with omeprazole were
compared. We also measure important parameters in sixty age and sex match healthy
individuals at baseline.
Results:
Mean age of patients was 31.8 year and there was no
significant difference regarding age, sex, body mass index, serum calcium, serum
alkaline phosphatase and parathyroid hormone between cases and controls. Although,
most of the patients were vitamin D deficient (mean = 29.7 nmol/l); compared to
controls serum 25 OH Vitamin D was higher (
P
= 0.005) and serum phosphate was
lower (
P
= 0.001) in patients. In addition, there was significant increase in alkaline
phosphatase (
P
=0.01) and borderline decrease in serum calcium (
P
= 0.057), thirty
days after treatment with omeprazole.
Conclusions:
High dose omeprazole after
thirty days in the presence of vitamin D deficiency affects bone turnover probably by
decreasing calcium absorption.
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