Internal Medicine and Medical Investigation Journal

ISSN: 2474-7750

Short Term Omeprazole Use and Markers of Calcium Homeostasis


Author(s): Afshin Amini1, Mahmoud Ali Kaykhaei2, Zahra Vaezi2, Alireza Bakhshipour

Several studies indicate a higher prevalence of fracture following long

term utilization of proton pump inhibitors, among them omeprazole is the most

widely used. However, the exact mechanisms lead to this complication are largely

unknown. We studied short term effects of omeprazole on some markers of calcium


Materials and Methods:

In thirty young adult patients with gastroe-

sophageal reflux, omeprazole was prescribed at 20 mg twice daily for thirty days.

Baseline characteristics as well as data after treatment with omeprazole were

compared. We also measure important parameters in sixty age and sex match healthy

individuals at baseline.


Mean age of patients was 31.8 year and there was no

significant difference regarding age, sex, body mass index, serum calcium, serum

alkaline phosphatase and parathyroid hormone between cases and controls. Although,

most of the patients were vitamin D deficient (mean = 29.7 nmol/l); compared to

controls serum 25 OH Vitamin D was higher (


= 0.005) and serum phosphate was

lower (


= 0.001) in patients. In addition, there was significant increase in alkaline

phosphatase (


=0.01) and borderline decrease in serum calcium (


= 0.057), thirty

days after treatment with omeprazole.


High dose omeprazole after

thirty days in the presence of vitamin D deficiency affects bone turnover probably by

decreasing calcium absorption.

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