Internal Medicine and Medical Investigation Journal

ISSN: 2474-7750

Study of Klebsiella Pneumonia Antibiotic-resistance of K1 and K2 Serotypes in NosocomialInfections with Hospital Origin


Author(s): Rezvan Doustipour1, Fatemeh KeshavarziÙ­1, Fariba Lahourpour

Klebsiella pneumonia

are the most pollutants of the hospital origin. The

aim of this study was to determine the antibiotic resistance pattern of Klebsiella

pneumonia in two serotypes K1 and K2 from samples collected with urinary tract infec-

tions and burn injuries in Kermanshah of Iran.

Materials and Methods:

This study was

performed on 140 samples collected from hospitals in Kermanshah for a period of 6

months. After confirmation of bacteria by phenotypic method, genotyping was done by

PCR of rmpA2 and magA1 genes. Subsequently, Antibiotic resistance pattern was

evaluated according to the CLSI 2017 regimen using 6 types of antibiotic disks.


The results of genotype determination showed that 76% of the samples were

related to K1 serotype and 24% of the samples were related to K2 serotype. In addition,

among the samples taken from the 35 urine, K1 showed an 80% prevalence (28

samples) and 20% were related to K2. Of the 35 samples examined from burn injuries,

71% of the samples were related to K1 and 29% related to K2. The antibiogram results

showed that the samples of K1 positive were resistant to Onloxacin and Nitrofurantoin

antibiotics and sensitive to Ceftoxime and limit to Ceftriaxone antibiotics. The interface

has the Trimethoprim and Cefazolin antibiotics. In addition, K2 serotype is susceptible

to Ceftoxime and resistant to Nitrofurantoin and intermediate mode for Cefazolin,

Forloxacin and Trimethoprim antibiotics. Additionally, the resistance k1 serotype is

higher than k2.


In both samples of urine and burn in the studied popula-

tion, the prevalence of serotype k1 was higher and in both groups, the most resistant to

antibiotics were Nitrofurantoin and onloxacin. In addition, the most commonly used

antibiotics that are recommended are Cefotaxime and Ceftriaxone, and resistant antibi-

otics that should be used less than Nitrofurantoin and Onloxacin

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